Goes to show how important titration and dosing (always) are:
> Less than a quarter of [MariTide] patients — 22.5% to 24.4% — experienced vomiting with the titrated dosing plans. Drugs that mimic the GLP-1 hormone tend to cause gastrointestinal side effects.
> Without titrating, roughly 65% to 85% of patients reported vomiting, he said.
> "Importantly, nobody dropped out of this trial," Bradner said. "The vast majority of symptoms were quite mild and well-tolerated by patients."
> He said the dosage was titrated over the course of eight weeks. In comparison, other companies have used a six-month titration period, he said.
Vomiting is hugely bad for your dental health, your digestive health, and your mental health, not to mention your quality of life. I just don’t see the point of this drug.
Goes to show how important titration and dosing (always) are:
> Less than a quarter of [MariTide] patients — 22.5% to 24.4% — experienced vomiting with the titrated dosing plans. Drugs that mimic the GLP-1 hormone tend to cause gastrointestinal side effects.
> Without titrating, roughly 65% to 85% of patients reported vomiting, he said.
> "Importantly, nobody dropped out of this trial," Bradner said. "The vast majority of symptoms were quite mild and well-tolerated by patients."
> He said the dosage was titrated over the course of eight weeks. In comparison, other companies have used a six-month titration period, he said.
Vomiting is hugely bad for your dental health, your digestive health, and your mental health, not to mention your quality of life. I just don’t see the point of this drug.
Oof, as a patient? Big pass!
Wow sounds like it’s not worth the weight loss!
Time for them to waive the white flag.