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Cloakster's avatar

Goes to show how important titration and dosing (always) are:

> Less than a quarter of [MariTide] patients — 22.5% to 24.4% — experienced vomiting with the titrated dosing plans. Drugs that mimic the GLP-1 hormone tend to cause gastrointestinal side effects.

> Without titrating, roughly 65% to 85% of patients reported vomiting, he said.

> "Importantly, nobody dropped out of this trial," Bradner said. "The vast majority of symptoms were quite mild and well-tolerated by patients."

> He said the dosage was titrated over the course of eight weeks. In comparison, other companies have used a six-month titration period, he said.

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Kirsten Whatley's avatar

Vomiting is hugely bad for your dental health, your digestive health, and your mental health, not to mention your quality of life. I just don’t see the point of this drug.

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