Great news that the results have been shared and they are applying to get it approved at the higher dose. Can't wait to hear about the higher dose zepbound trial results (20mg and 25mg dose) I'm a slow responder so I speculate I need a higher dose. Wish I could lose 10 lbs a month..I just lose 1 lb and that's with a lot of hard work.
I figured out why these #s were so high. These are the trial product estimand values (17.5% for 2.4mg and 20.7% for 7.2mg). When you look at the treatment policy estimand you actually get 15.6% and 18.7% respectively. Novo likes to report the higher, rosier #s. Lilly reports the lower. The trial product estimate lets you toss out those who didn’t adhere to the protocol (illness, titration issues, etc).
Here’s the question: how’d they get 2.4mg to 17.5% performance in 72 weeks? Did they over sample women more than usual? 2.4mg was just 15.6% is the 68 week STEP-1 and 13.7% in the 72 week SURMOUNT-5 (edit: which was the semaglutide vs tirzepatide head-to-head).
Doesn’t that call into question the strength of the 7.2mg results in this same trial?
Great news that the results have been shared and they are applying to get it approved at the higher dose. Can't wait to hear about the higher dose zepbound trial results (20mg and 25mg dose) I'm a slow responder so I speculate I need a higher dose. Wish I could lose 10 lbs a month..I just lose 1 lb and that's with a lot of hard work.
I figured out why these #s were so high. These are the trial product estimand values (17.5% for 2.4mg and 20.7% for 7.2mg). When you look at the treatment policy estimand you actually get 15.6% and 18.7% respectively. Novo likes to report the higher, rosier #s. Lilly reports the lower. The trial product estimate lets you toss out those who didn’t adhere to the protocol (illness, titration issues, etc).
Is there space in OTP to talk about pain relief from osteoarthritis and maybe talk Rybelsus?
Here’s the question: how’d they get 2.4mg to 17.5% performance in 72 weeks? Did they over sample women more than usual? 2.4mg was just 15.6% is the 68 week STEP-1 and 13.7% in the 72 week SURMOUNT-5 (edit: which was the semaglutide vs tirzepatide head-to-head).
Doesn’t that call into question the strength of the 7.2mg results in this same trial?
I’m happy for all the Ozempic/Wegovy peeps! News just happens faster than we can keep up. Thanks, Dave!!!