Potentially I would-in maintenance. Being on Zepbound and well along in my journey, I'm watching oral VK2735 with interest focusing on tolerability and effectiveness. If and when it hits the market, I should be a couple years into maintenance which might be a good time to give it a try. It's interesting also that the company is studying maintenance results, so we can see where they are positioning...We shall see.
In 2 years I lost 120 pounds on Zepbound and an now considered having a "normal BMI". I would hesitate to switch from the shot since it worked so well for me and currently on 10mg maintenance dose. I tried taking the shot every 9 or 10 days but the food noise started creeping back to I am staying at once per week. This medication is nothing short of amazing!!
Lilly's oral GLP-1, Foundayo (orforglipron), was associated with significant reductions in predicted long-term risk of type 2 diabetes and cardiovascular disease
October 1, 2026
In post-hoc analyses of ATTAIN-1, Foundayo 17.2 mg was associated with a predicted 57% and 18% reduction in risk of type 2 diabetes and cardiovascular disease vs. placebo
Combined with recent research on the savings tied to weight loss, these findings suggest Foundayo could help reduce long-term spending for patients and healthcare systems
results from post-hoc analyses of ATTAIN-1 showing that Foundayo was associated with significant reductions in predicted 10-year risk of type 2 diabetes and cardiovascular disease in adults with obesity or overweight with a weight-related medical problem.
Obesity is strongly associated with an increased risk of developing both cardiovascular disease and type 2 diabetes.1 Through its proven benefit in weight loss and its ability to improve certain cardiovascular risk factors like blood sugar, blood pressure and cholesterol,
Foundayo may be a meaningful treatment option for the more than 100 million U.S. adults living with obesity.2 The findings of these analyses were published in Diabetes, Obesity and Metabolism.
"For many people living with obesity or overweight, the concern isn't just what the scale says today, it's whether their future could include type 2 diabetes or heart disease," said Thomas Seck, M.D., senior vice president of product development, Lilly Cardiometabolic Health.
"These additional analyses of ATTAIN-1 show that Foundayo was associated with a lower predicted long-term risk of both conditions, in addition to meaningful weight loss.
We've also seen evidence that treating obesity and reducing the risk of its downstream consequences, like cardiovascular disease and type 2 diabetes, can meaningfully lower healthcare costs.
That gives us real optimism about what long-term Foundayo use could mean, both for patients and for the broader healthcare system."
In these analyses, modeling showed that Foundayo was associated with clinically meaningful improvements in predicted 10-year risk of type 2 diabetes and cardiovascular disease across all three doses.
At 72 weeks, participants taking Foundayo 5.5 mg, 9 mg and 17.2 mg showed an estimated 45.0%, 50.0% and 57.0% reduction, respectively, in predicted type 2 diabetes risk versus placebo.
Participants taking Foundayo 17.2 mg also showed an estimated 18.0% reduction in predicted cardiovascular disease risk versus placebo.
I would not switch to Wegovy pill, due to the requirements. I would switch to Foundayo and hope to once I reach my next goal. I am self pay, so happy to spend less.
I would consider the dual agonist pill Viking is developing, so it would be easier to travel with. Obviously I will need to wait for that. I wouldn't want it until I was in maintenance anyway. But I would not leave my GIP behind to go on a pill. The Wegovy and Foundayo pills don't interest me.
My main question would be whether the pills provide the non-weight-related health benefits that I have experienced with the injectable tirzepatide. Until that is determined (and that will take years, IMO), I'll stick with my inconvenient injections. But if they really are found to be health-impact equivalent, then I would certainly consider switching to a pill.
I would consider going on the pill once I reach my goal and I’m on maintenance. The reason I would do this is because I’m paying out-of-pocket and it would be less money for me going forward, as a retired individual. I honestly don’t know how long I will be able to afford Zepbound since I am on a fixed income. I do not qualify for the bridge program because my prescription drug plan is rolled up in my retiree health insurance. It is not a standalone part D and it is not an advantage plan. So even though Medicare is my primary and I pay for it every month I do not qualify for the bridge program.
I would switch if it was as or more effective than my Zepbound. I would like a more consistent dose and would even be willing to do daily shots if I felt more control. Currently wanting to switch to Kwikpen but insurance won't cover.
I’ve been on the shot for over 2 1/2 years, I’ve been fortunate that my insurance covers my injections. I pay $25 for a three month supply. So if something were to happen and my insurance wouldn’t cover it anymore, sure I would consider the pill but at this point if you can beat that price, I’ll stay with the shot.
Interestingly, for two years, I avoided going on injections and tried the other oral options, including phentermine and Contrave and Qsymia. I had lost 15 to 20 pounds. My doctor was suggesting injections all along, but the cost was very high. Early this year when I expressed my frustration with the oral meds, she suggested injections again. The price had come down to $299 for starting on Zepbound so I started. My fears about having to take the medication long-term and being on something injectable were so quickly gone. These meds are life-changing and I am now such an advocate.
As the cost got quite high over 5mg, I switched to compounded a couple of months ago.
I love the injections, it’s easy to remember, and I love that my dosing and frequency are easily customized.
I would choose to stay on the injections. I would consider a tablet if there was a reason to make a switch. Having said that, don’t we need to ingest a much higher dose of the medication to get to the same effectiveness with an oral med? And what possible effect would that have?
Sidenote, in seven months, I’ve lost 30 (more) pounds and I am at a weight lower than I thought possible, less than I have weighed in probably 30 years.
The injection is working well for me. I would not switch to a pill at this stage. However, I’m open to exploring another option in the future should my needs change.
Thanks for asking this thought provoking question. I’m interested in how the pill is working for first time users of GLP 1 medication.
Possibly. At the 40 week mark I’ve began getting injection site reactions with each zepbound injection, regardless of injection site. If they get worse, I may be forced to go to another option.
Girlfriend on Zepbound 7mg Lilly direct (2.5, 5, 7.5). Went from 200 pounds, now 133, in over a year. 5 4. A1c 4.8.
No side efects, none. Never.
Considering foundayo. Don't know equivalent. 9mg, 14mg or 17mg, that will help loose to 125, or at least weight maintenance, Wo side efects.
Also Start tirzepatide for me
Dieted 180 to 142, male 5 10, 12% body fat 70 yr. Will restart gym cause sciatica, shoulder
For metabolism, Fatty liver, Artritis, Lower insulin resistance.
Potentially I would-in maintenance. Being on Zepbound and well along in my journey, I'm watching oral VK2735 with interest focusing on tolerability and effectiveness. If and when it hits the market, I should be a couple years into maintenance which might be a good time to give it a try. It's interesting also that the company is studying maintenance results, so we can see where they are positioning...We shall see.
Staying put on the shots.
In 2 years I lost 120 pounds on Zepbound and an now considered having a "normal BMI". I would hesitate to switch from the shot since it worked so well for me and currently on 10mg maintenance dose. I tried taking the shot every 9 or 10 days but the food noise started creeping back to I am staying at once per week. This medication is nothing short of amazing!!
Lilly's oral GLP-1, Foundayo (orforglipron), was associated with significant reductions in predicted long-term risk of type 2 diabetes and cardiovascular disease
October 1, 2026
In post-hoc analyses of ATTAIN-1, Foundayo 17.2 mg was associated with a predicted 57% and 18% reduction in risk of type 2 diabetes and cardiovascular disease vs. placebo
Combined with recent research on the savings tied to weight loss, these findings suggest Foundayo could help reduce long-term spending for patients and healthcare systems
results from post-hoc analyses of ATTAIN-1 showing that Foundayo was associated with significant reductions in predicted 10-year risk of type 2 diabetes and cardiovascular disease in adults with obesity or overweight with a weight-related medical problem.
Obesity is strongly associated with an increased risk of developing both cardiovascular disease and type 2 diabetes.1 Through its proven benefit in weight loss and its ability to improve certain cardiovascular risk factors like blood sugar, blood pressure and cholesterol,
Foundayo may be a meaningful treatment option for the more than 100 million U.S. adults living with obesity.2 The findings of these analyses were published in Diabetes, Obesity and Metabolism.
"For many people living with obesity or overweight, the concern isn't just what the scale says today, it's whether their future could include type 2 diabetes or heart disease," said Thomas Seck, M.D., senior vice president of product development, Lilly Cardiometabolic Health.
"These additional analyses of ATTAIN-1 show that Foundayo was associated with a lower predicted long-term risk of both conditions, in addition to meaningful weight loss.
We've also seen evidence that treating obesity and reducing the risk of its downstream consequences, like cardiovascular disease and type 2 diabetes, can meaningfully lower healthcare costs.
That gives us real optimism about what long-term Foundayo use could mean, both for patients and for the broader healthcare system."
In these analyses, modeling showed that Foundayo was associated with clinically meaningful improvements in predicted 10-year risk of type 2 diabetes and cardiovascular disease across all three doses.
At 72 weeks, participants taking Foundayo 5.5 mg, 9 mg and 17.2 mg showed an estimated 45.0%, 50.0% and 57.0% reduction, respectively, in predicted type 2 diabetes risk versus placebo.
Participants taking Foundayo 17.2 mg also showed an estimated 18.0% reduction in predicted cardiovascular disease risk versus placebo.
I would not switch to Wegovy pill, due to the requirements. I would switch to Foundayo and hope to once I reach my next goal. I am self pay, so happy to spend less.
I would consider the dual agonist pill Viking is developing, so it would be easier to travel with. Obviously I will need to wait for that. I wouldn't want it until I was in maintenance anyway. But I would not leave my GIP behind to go on a pill. The Wegovy and Foundayo pills don't interest me.
I feel the same way about moving to a different medication without the GIP
My main question would be whether the pills provide the non-weight-related health benefits that I have experienced with the injectable tirzepatide. Until that is determined (and that will take years, IMO), I'll stick with my inconvenient injections. But if they really are found to be health-impact equivalent, then I would certainly consider switching to a pill.
I would consider going on the pill once I reach my goal and I’m on maintenance. The reason I would do this is because I’m paying out-of-pocket and it would be less money for me going forward, as a retired individual. I honestly don’t know how long I will be able to afford Zepbound since I am on a fixed income. I do not qualify for the bridge program because my prescription drug plan is rolled up in my retiree health insurance. It is not a standalone part D and it is not an advantage plan. So even though Medicare is my primary and I pay for it every month I do not qualify for the bridge program.
I would switch if it was as or more effective than my Zepbound. I would like a more consistent dose and would even be willing to do daily shots if I felt more control. Currently wanting to switch to Kwikpen but insurance won't cover.
I prefer the ability to adjust medication on a vial. My choice would the vial over the pill.
I would not change to a pill because I hear the side effects can be more severe and I have not had any side effects with the injections.
I’ve been on the shot for over 2 1/2 years, I’ve been fortunate that my insurance covers my injections. I pay $25 for a three month supply. So if something were to happen and my insurance wouldn’t cover it anymore, sure I would consider the pill but at this point if you can beat that price, I’ll stay with the shot.
Interestingly, for two years, I avoided going on injections and tried the other oral options, including phentermine and Contrave and Qsymia. I had lost 15 to 20 pounds. My doctor was suggesting injections all along, but the cost was very high. Early this year when I expressed my frustration with the oral meds, she suggested injections again. The price had come down to $299 for starting on Zepbound so I started. My fears about having to take the medication long-term and being on something injectable were so quickly gone. These meds are life-changing and I am now such an advocate.
As the cost got quite high over 5mg, I switched to compounded a couple of months ago.
I love the injections, it’s easy to remember, and I love that my dosing and frequency are easily customized.
I would choose to stay on the injections. I would consider a tablet if there was a reason to make a switch. Having said that, don’t we need to ingest a much higher dose of the medication to get to the same effectiveness with an oral med? And what possible effect would that have?
Sidenote, in seven months, I’ve lost 30 (more) pounds and I am at a weight lower than I thought possible, less than I have weighed in probably 30 years.
The injection is working well for me. I would not switch to a pill at this stage. However, I’m open to exploring another option in the future should my needs change.
Thanks for asking this thought provoking question. I’m interested in how the pill is working for first time users of GLP 1 medication.
Possibly. At the 40 week mark I’ve began getting injection site reactions with each zepbound injection, regardless of injection site. If they get worse, I may be forced to go to another option.