Well….I have to respectfully disagree with the “evidence.” Some of us are super-responders and have lost all of the excess weight on the lowest dose of Zepbound. I know I’m in the minority, but that’s why we need for our practitioners to have the ability to tailor dosages with compounds. In 41 weeks, I’m down 62 pounds and only on 2.5 mg bc they don’t make a lower dose. I am no longer pre-diabetic, hypertensive, and full of arthritis pain. I would go to a lower dose if I could because I still have some unpleasant side effects. I know there are many others like me because I’ve seen their posts on other social media platforms.
You can “carefully” inject your 2.5mg Zepbound pen into the needle end of a Luer Lock Syringe, but with the needle removed. Then put the needle back on and inject the .50ml of the liquid medicine into a clean glass vile or insulin pen cartridge. Venting with a separate needle tip will release the pressure in the vile. You will also need to add .50ml of sterilized BAC water to your medicine for a total amount of 1ml/100 units.
100 unit syringe now equals your 2.5mg of medicine.
If you divide it into three 33 unit doses, it will be .83mg per dose. Or divide in half for two doses of 50 units/ 1.25mg per dose.
Thank you! I am so grateful I’ve been able to respond so well. I know it’s very rough for others, and I feel badly that they’re struggling at the highest doses. But, now you know why I’m so pro-compounding. It’s not a rebellious thing against name brand as much as a necessity for me, personally.
I think a whole post needs to be done to explain the difference between Microdosing, split dosing and divided dosing, compared to minimum dose dosing.
Example: I divide my 15mg dose of Zepbound into three 5mg doses and take it on a Monday, Wednesday, Friday schedule totaling 15mg weekly.
There are a lot of people dividing their doses up, because it reduces the severity of the side effects. But, they are calling it Microdosing, when in actuality it is divided or split dosing. But they hear the Influencers and others say the word Microdosing so they think that’s what they are doing.
As with any drug, response is dependent on the individual. I had too much suppression on 2.5mg, and ended up losing more than my doctor was comfortable with in a short period of time. If my insurance had covered vials, I would have benefited from a microdose. These studies give us averages and generalizations. They don’t speak to the experience of the individual. Even doctors you’ve interviewed on your show, like Spencer Nadolsky, has said that while in general micro dosing is not useful or backed by science, he has had the occasional patient where it was necessary. Most doctors will tell you that many of their patients do not require the highest doses to see results as high as those seen in the studies. In general is microdosing useful? No. But all dosing should be based on individual response.
I guess my concern is people getting caught up in the hype and missing what the data actually tells us. Some people may benefit from microdosing, while some may require megadosing. In general the data we have tells us higher doses lead to greater weight loss.
I do wholeheartedly agree, patients should be treated as individuals.
I totally hear you on that - and I must admit I roll my eyes at the wellness influencers that claim microdosing is THE way for folks with obesity. I think my reaction in part also comes from the many folks on Reddit (I spend too much time there) advising people to move to the highest doses without taking into account individual response, even when people are having good results at lower doses, or sometimes even when people are having rough side effects on lower doses.
I understand this view on Microdosing, but I am going to continue to microdose with my Ozempic because I take Ozempic together with Vyvanse. The two work together great as a appetite suppressant I take 0.25 of Ozempic.
Again, I should have better defined microdosing. For purposes of this article, I was speaking of microdosing as: “a fractional amount of the lowest dose, once weekly”.
.25 mg is the lowest dose of Ozempic by this definition, not a microdose.
If you’re already getting obesity treatment through your PCP and they have effectively exhausted all the ways to get you covered, not much TBH. But the issue with PCPs is that many will flat out tell patients that they don’t have time to deal with PA’s, and many lack the expertise in how to win them. Something that Ro excels at.
I think the idea of micro-dosing is also attractive to people as a means of saving money. Make that vial last as long as they can. Understandable, given the price, but with the vials being “single-use” with no preservative, it’s not without risks.
Respectfully disagree. At BMI of 34 I was clinically obese. I am a 5ft shorty with over 50lbs to lose and a multitude of comorbidites and autoimmune issues besides obesity. I was extremely concerned about side effects due to past health issues so my doc decided to microdose as a way to ease in and hopefully mitigate some of those concerns. I have been half the 2.5 starting dose since February 1 and have lost 20lbs. Slow and steady and I’m thrilled with my progress, zero side effects, drastic decrease in food noise and inflammation. My doctor considers me a “super responder”. And Dr. Tyna is my super hero. Honestly if it wasn’t for her starting the conversation and enlightening me regarding microdosing I would have likely never been brave enough to try. I feel like owe her a lot because for the first time in years I feel like I’m getting my life back. As she says time and time again - the peptide isn’t the poison - the dose is.
Well….I have to respectfully disagree with the “evidence.” Some of us are super-responders and have lost all of the excess weight on the lowest dose of Zepbound. I know I’m in the minority, but that’s why we need for our practitioners to have the ability to tailor dosages with compounds. In 41 weeks, I’m down 62 pounds and only on 2.5 mg bc they don’t make a lower dose. I am no longer pre-diabetic, hypertensive, and full of arthritis pain. I would go to a lower dose if I could because I still have some unpleasant side effects. I know there are many others like me because I’ve seen their posts on other social media platforms.
But 2.5 mg is not a microdose it’s the lowest dose, but it’s not a microdose. Microdose would be a fraction of the lowest dose once weekly.
If 1.5 or 1.0 were available, I believe that would be my perfect maintenance dose.
You can “carefully” inject your 2.5mg Zepbound pen into the needle end of a Luer Lock Syringe, but with the needle removed. Then put the needle back on and inject the .50ml of the liquid medicine into a clean glass vile or insulin pen cartridge. Venting with a separate needle tip will release the pressure in the vile. You will also need to add .50ml of sterilized BAC water to your medicine for a total amount of 1ml/100 units.
100 unit syringe now equals your 2.5mg of medicine.
If you divide it into three 33 unit doses, it will be .83mg per dose. Or divide in half for two doses of 50 units/ 1.25mg per dose.
And also, I think that’s so amazing for you that you had such amazing progress!!
Thank you! I am so grateful I’ve been able to respond so well. I know it’s very rough for others, and I feel badly that they’re struggling at the highest doses. But, now you know why I’m so pro-compounding. It’s not a rebellious thing against name brand as much as a necessity for me, personally.
I think a whole post needs to be done to explain the difference between Microdosing, split dosing and divided dosing, compared to minimum dose dosing.
Example: I divide my 15mg dose of Zepbound into three 5mg doses and take it on a Monday, Wednesday, Friday schedule totaling 15mg weekly.
There are a lot of people dividing their doses up, because it reduces the severity of the side effects. But, they are calling it Microdosing, when in actuality it is divided or split dosing. But they hear the Influencers and others say the word Microdosing so they think that’s what they are doing.
As with any drug, response is dependent on the individual. I had too much suppression on 2.5mg, and ended up losing more than my doctor was comfortable with in a short period of time. If my insurance had covered vials, I would have benefited from a microdose. These studies give us averages and generalizations. They don’t speak to the experience of the individual. Even doctors you’ve interviewed on your show, like Spencer Nadolsky, has said that while in general micro dosing is not useful or backed by science, he has had the occasional patient where it was necessary. Most doctors will tell you that many of their patients do not require the highest doses to see results as high as those seen in the studies. In general is microdosing useful? No. But all dosing should be based on individual response.
I guess my concern is people getting caught up in the hype and missing what the data actually tells us. Some people may benefit from microdosing, while some may require megadosing. In general the data we have tells us higher doses lead to greater weight loss.
I do wholeheartedly agree, patients should be treated as individuals.
I totally hear you on that - and I must admit I roll my eyes at the wellness influencers that claim microdosing is THE way for folks with obesity. I think my reaction in part also comes from the many folks on Reddit (I spend too much time there) advising people to move to the highest doses without taking into account individual response, even when people are having good results at lower doses, or sometimes even when people are having rough side effects on lower doses.
I understand this view on Microdosing, but I am going to continue to microdose with my Ozempic because I take Ozempic together with Vyvanse. The two work together great as a appetite suppressant I take 0.25 of Ozempic.
Again, I should have better defined microdosing. For purposes of this article, I was speaking of microdosing as: “a fractional amount of the lowest dose, once weekly”.
.25 mg is the lowest dose of Ozempic by this definition, not a microdose.
What is the benefit of Ro if your ins does not pay and you have a primary care dr.? I have been curious about this.
If you’re already getting obesity treatment through your PCP and they have effectively exhausted all the ways to get you covered, not much TBH. But the issue with PCPs is that many will flat out tell patients that they don’t have time to deal with PA’s, and many lack the expertise in how to win them. Something that Ro excels at.
I think the idea of micro-dosing is also attractive to people as a means of saving money. Make that vial last as long as they can. Understandable, given the price, but with the vials being “single-use” with no preservative, it’s not without risks.
Respectfully disagree. At BMI of 34 I was clinically obese. I am a 5ft shorty with over 50lbs to lose and a multitude of comorbidites and autoimmune issues besides obesity. I was extremely concerned about side effects due to past health issues so my doc decided to microdose as a way to ease in and hopefully mitigate some of those concerns. I have been half the 2.5 starting dose since February 1 and have lost 20lbs. Slow and steady and I’m thrilled with my progress, zero side effects, drastic decrease in food noise and inflammation. My doctor considers me a “super responder”. And Dr. Tyna is my super hero. Honestly if it wasn’t for her starting the conversation and enlightening me regarding microdosing I would have likely never been brave enough to try. I feel like owe her a lot because for the first time in years I feel like I’m getting my life back. As she says time and time again - the peptide isn’t the poison - the dose is.